HORDB

ID: hor002065
Uniprot ID: P80090(30-66)
Protein name: Molluscan insulin-related peptide 3 B chain
Gene name: NA
Organism: Lymnaea stagnalis (Great pond snail) (Helix stagnalis)
Family: Insulin family
Source: animal
Expression: Expressed in the cerebral light-green cells which are giant neuroendocrines cells involved in the control of growth.
Disease: NA
Comments: NA
Taxonomy: Lymnaea (genus), Lymnaeidae (family), Lymnaeoidea (superfamily), Hygrophila, Panpulmonata, Euthyneura, Heterobranchia (subclass), Gastropoda (class), Mollusca (phylum), Lophotrochozoa, Spiralia, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
GO MF: GO:0005179 hormone activity
GO BP: GO:0007165 signal transduction
GO CC: GO:0005576 extracellular region; GO:0030133 transport vesicle; GO:0031410 cytoplasmic vesicle

Sequence: TTQHTCSILSRPHPRGLCGSTLANMVQWLCSTYTTSS
Length: 37(30-66)
Propeptide: MASVHLTLTKAFMVTVFLTLLLNVSITRGTTQHTCSILSRPHPRGLCGSTLANMVQWLCSTYTTSSKVKRQAEPDEEDDAMSKIMISKKRALSYLTKRESRPSIVCECCFNQCTVQELLAYC
Signal peptide: MASVHLTLTKAFMVTVFLTLLLNVSITRG
Modification: NA
Glycosylation: NA
Mutagenesis: NA

Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)

hor002065_AF2.pdb

hor002065_ESM.pdb

Mass:	468188	Formula:	C170H273N51O55S4
Absent amino acids:	DEFK	Common amino acids:	T
pI:	8.52	Basic residues:	4
Polar residues:	20	Hydrophobic residues:	8
Hydrophobicity:	-18.11	Boman Index:	-5456
Half-Life:	7.2 hour	Half-Life Yeast:	>20 hour
Half-Life E.Coli:	>10 hour	Aliphatic Index	63.24
Instability Index:	2240.54	Extinction Coefficient cystines:	7115
Absorbance 280nm:	197.64

PubMed ID: 1572366
Title: Isolation and chemical characterization of a novel insulin-related neuropeptide from the freshwater snail, Lymnaea stagnalis.